article · Journal of Basic Microbiology
This research developed an innovative method for biosynthesising silver nanoparticles (Ag NPs) using yeast β-glucan nanoparticles (βG NPs) as a template, avoiding additional chemical processes. Physicochemical assessments confirmed the formation of Ag NPs and their successful capping within the βG NPs. The resulting βG-Ag NPs composite, along with plain Ag NPs, demonstrated strong bactericidal activity against both Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Salmonella Typhimurium, Pseudomonas aeruginosa). Microscopic analysis showed the nanocomposite effectively destroyed bacterial cells. The study concludes that this novel biosynthesis and the combined βG-Ag NPs nanocomposite offer powerful antibacterial candidates with reduced potential toxicity.
Developing new antibacterial agents is crucial due to rising antimicrobial resistance and the toxicity of existing options. This research offers a promising approach to create effective and potentially safer antibacterial materials by using natural biopolymers to stabilise metallic nanoparticles, addressing a significant public health challenge.
This early-stage research indicates a potential pathway for developing new antibacterial agents. The βG-Ag NPs nanocomposite could be applied in areas requiring antimicrobial properties, such as medical devices, wound dressings, or hygiene products. Its reduced potential toxicity, as highlighted, makes it an attractive candidate for further development towards real-world applications.
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Nanometals (NM) frequently possess potent antimicrobial potentials to combat various pathogens, but their elevated biotoxicity limits their direct applications. The biosynthesis of NM and their capping/conjugation with natural biopolymers can effectually enhance NM stability and diminish such toxicity. Yeast β-glucan (βG), from Saccharomyces cerevisiae, was extracted and transformed to nanoparticles (NPs) using alkali/acid facile protocol. The βG NPs were innovatively employed for direct biosynthesis of silver nanoparticles (Ag NPs) without extra chemical processes. The physicochemical assessments (Fourier-transform infrared, X-ray diffraction, and transmission electron microscopy) validated NPs formation, interaction, and interior capping of Ag NPs in βG NPs. The synthesized βG NPs, Ag NPs, and βG-Ag NPs composite were negatively charged and had minute particle sizes with mean diameters of 58.65, 6.72, and 63.88 nm, respectively. The NPs (plain Ag NPs and composited βG-Ag NPs) exhibited potent comparable bactericidal actions, opposing Gram<sup>+</sup> (Staphylococcus aureus) and Gram<sup>-</sup> (Escherichia coli, Salmonella Typhimurium, and Pseudomonas aeruginosa). Scanning micrographs, of treated S. aureus and S. Typhimurium with βG-Ag NPs, elucidated the powerful bactericidal actions of nanocomposite for destructing pathogens' cells. The inventive Ag NPs biosynthesis with βG NPs and the combined βG-Ag NPs nanocomposites could be impressively recommended as powerful antibacterial candidates with minor potential toxicity.
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DOI: 10.1002/jobm.202100195
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