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article · Annals of Epidemiology

Initiation of dolutegravir vs efavirenz on 12- and 24-month weight, body mass index, blood pressure, and incident hypertension: A target trial emulation

2026Open accessUniversity of Pretoria

Abstract

Dolutegravir was associated with greater increases in weight, systolic BP, and incident hypertension over 24-months, particularly in the first 12-months. Future research is needed to determine whether this reflects a direct effect of dolutegravir or the weight-suppressing effects of efavirenz.

Research topics

  • HIV-related health complications and treatments
  • HIV/AIDS drug development and treatment
  • Diabetes, Cardiovascular Risks, and Lipoproteins

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DOI: 10.1016/j.annepidem.2026.110074

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