Inflammatory cytokines and quality of life response to weight reduction in obese patients with bronchial asthma

Abstract

Background: Globally, about 20% of the population are affected with asthma. However, public health is adversely affected with asthma and obesity. Objective: The target of the present study was to measure influence of weight loss on quality of life and Inflammatory cytokines of obese asthmatic patients. Material and Methods: Eighty obese asthmatic patients; the mean of their age was 42.71 ± 6.35 year and body mass index (BMI) was 32.85 ± 3.16 Kg/m2. Participants equally assigned in group (A) received weight reducing program, where group (B) received no therapeutic intervention. Results: The Health-related quality of life (SF-36 HRQL) subscale scores, interleukin-10 (IL-10) and Asthma Control Test (ACT) improved significantly, where, the mean values of BMI, TNF-α and IL-6 were significantly reduced in group (A). While group (B) had no significant changes in their parameters. In addition, the differences between both groups were not significant at the end of the study. Conclusion: Inflammatory cytokines and quality of life parameters improved with lifestyle modification among obese asthmatic patients.