article · Alzheimer s & Dementia
Our findings confirm the role of APOE e4 in AD risk among African ancestries and its smaller effect size relative to NHW populations, and replicate three additional loci (ABCA7, BCKDK/KAT8, TREML2) that show nominal associations with AD. Admixture and principal component analysis underscores the extensive genetic variability among the African diaspora. Ongoing data collection through the AfDC and READD-ADSP at large to reach 13,000 total participants across global populations will continue to enhance understanding of AD pathogenesis. By leveraging genetic diversity from multiple populations, we can ultimately accelerate the discovery of interventions that benefit all communities.
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DOI: 10.1002/alz70855_106725
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