article · South African Journal of Botany
Evaluation of the methanolic extract of the plant Linaria scariosa provides laboratory evidence supporting its traditional use in the Aures region of Algeria for wound healing. Phytochemical screening reveals moderate levels of polyphenols and flavonoids alongside other active secondary metabolites. Across four laboratory tests, the extract demonstrated moderate antioxidant properties. It also showed dose-dependent anti-inflammatory effects by reducing protein denaturation, achieving roughly 41 percent inhibition at 500 micrograms per millilitre. In clotting assessments, the extract significantly accelerated plasma re-calcification times compared to controls, demonstrating notable hemostatic capability. In addition, tests for photoprotection revealed an estimated sun protection factor of 38.46, reflecting a strong capacity to absorb ultraviolet radiation. These combined biological activities indicate potential utility for the extract as an active ingredient in topical skincare and cosmetic preparations.
Traditional botanical remedies often lack scientific validation despite generations of local use. Demonstrating that Linaria scariosa possesses sun-protective, blood-clotting, anti-inflammatory, and antioxidant properties provides empirical evidence for its traditional wound healing role. Identifying plants with high sun protection factors and multi-action skin recovery traits aids the development of naturally derived, multifunctional treatments for wound care and skin defence.
The extract is an early-stage candidate for cosmetics, sunscreens, and topical wound management products. Skincare and personal care formulators could explore the extract as an active ingredient providing both ultraviolet protection and hemostatic or anti-inflammatory benefits. However, because all reported findings derive from in vitro assays, further safety profiling, extraction standardisation, and in vivo testing are required before formulating commercial skincare agents or medical dressings.
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Recently, plant-derived extracts gained considerable attention as skincare agents, because of their capacity to exert a broad spectrum of biological activities, including their power to absorb ultraviolet radiation, their antioxidant, anti-inflammatory and hemostatic properties. In this context, the study focused on the evaluation of in vitro pharmacological activities of the methanolic extract obtained from the species Linaria scariosa. The plant is used by the local populations of Aures region (Algeria) for wound healing and its traditional applications will be validated. The quantification of the total phenolic and flavonoid content was performed spectrophotometrically using Folin-Ciocalteu and trichloroaluminum methods. The antioxidant activity was determined by four different assays including ferric reducing antioxidant power, total antioxidant capacity, ferric thiocyanate assay and the antioxidant activity by potentiometric method. Furthemore, the in vitro anti-inflammatory activity was assessed by albumin denaturation method, the photoprotective effect was evaluated by the measurment of sun protection factor (SPF) and the hemostatic activity was carried out by the determination of plasma re-calcification time (PRT). Result of the phytochemical screening from the methanolic extract was found to contain several secondary metabolites known for their biological properties. Moderate contents of polyphenols and flavonoids were estimated. The MeOH extract possessed moderate antioxidant activity for various tested assays and had the ability to inhibit thermally-induced protein denaturation in a dose-dependent manner with a percentage of 40.98% at 500 μg/ml. Moreover, this plant extract significantly shortened the clotting time compared to the control group and had a higher capacity to absorb UV radiations with a sun protection factor estimated at 38.46 ± 0.22. The methanolic extract from L. scariosa could be used in cosmetic formulations and as a skincare agent.
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DOI: 10.1016/j.sajb.2020.01.003
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