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article · Alzheimer s & Dementia

Improving Genotype Imputation of African‐derived Genetic Variants in Studies of Alzheimer's Disease

2025Open accessUniversity of Ibadan

Abstract

The use of meta-imputation to better match the genetic background of the DAWN dataset through the use of multiple imputation references significantly increases the density and quality of the resulting genotypic dataset, enabling more powerful studies of AD genetics. This demonstrates the utility of meta-imputation for better matching the genetic background of samples when performing imputation.

Research topics

  • Genetic Associations and Epidemiology
  • Forensic and Genetic Research
  • Alzheimer's disease research and treatments

Sustainable Development Goals

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DOI: 10.1002/alz70855_106790

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