article · Clinical Pharmacokinetics

Importance of Lysosomal Trapping and Plasmodium Parasite Infection on the Pharmacokinetics of Pyronaridine: A Physiologically Based Pharmacokinetic Model-Based Study

Wan‐Yu Chu
Esperança Sevene
Kassoum Kayentao
Vivi Maketa
Umberto D’Alessandro
Anifa Valá
Gustave Kasereka
Alwin D. R. Huitema
Japhet Kabalu Tshiongo
Jangsik Shin
Doudou Malekita Yobi
Hypolite Muhindo Mavoko
Wietse M. Schouten
Freddy-Arnold Kabasele
Thomas P. C. Dorlo

20252 citationsOpen accessUniversité de Kinshasa (UNIKIN)

Abstract

This study demonstrates the value of PBPK modeling in elucidating key pharmacokinetic mechanisms, revealing the critical roles of lysosomal sequestration, Hb level, and parasitemia in pyronaridine disposition.

Research topics

HIV/AIDS drug development and treatment
Antibiotics Pharmacokinetics and Efficacy
Pharmacological Effects and Toxicity Studies

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DOI: 10.1007/s40262-025-01581-6

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