article · PLoS ONE

Impact of treatment and re-treatment with artemether-lumefantrine and artesunate-amodiaquine on selection of Plasmodium falciparum multidrug resistance gene-1 polymorphisms in the Democratic Republic of Congo and Uganda

Vito Baraka
Michael Alifrangis
Carolyn Nabasumba
Filbert Francis
Hypolite Muhindo Mavoko
Pascal Lutumba
Jean‐Pierre Van Geertruyden

201830 citationsOpen accessUniversité de Kinshasa (UNIKIN)

Abstract

We found limited impact of (re-)treatment with AL or ASAQ on selection for Pfmdr1 variants and haplotypes associated with resistance to partner drugs. These findings further supplement the evidence use of same or alternative ACTs as a rescue therapy for recurrent P.falciparum infections. Continued monitoring of genetic signatures of resistance is warranted to timely inform malaria (re-)treatment policies and guidelines.

Research topics

Malaria Research and Control
Drug-Induced Hepatotoxicity and Protection
Mosquito-borne diseases and control

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1371/journal.pone.0191922

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