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article · Annals of Medicine and Surgery

Impact of IDH mutation and adjuvant chemo(radio)therapy on survival outcome in grade II/III astrocytoma: a retrospective cohort study based on SEER database

2025Open accessAlexandria University

Abstract

The mIDH had better 2-year relative survival compared to wIDH across all treatment modalities. Adjuvant chemotherapy had more than 20% survival benefit compared to radiotherapy in mIDH and wIDH. These results highlight adjuvant chemotherapy as the modality of choice for mIDH to improve the survival outcome and avoid radiotherapy's unfavorable side effects. The study was registered at Clinicaltrial.gov with identification number of NCT06620926.

Research topics

  • Glioma Diagnosis and Treatment
  • Vascular Malformations Diagnosis and Treatment
  • Brain Metastases and Treatment

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DOI: 10.1097/ms9.0000000000003172

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