Impact of Alkaline Ionized Water on Improving Selected Outcomes for Hemodialysis Patients: A Randomized Controlled Trial

Abstract

Background: Alkaline ionized water may offer a safe and potentially beneficial strategy for the management of metabolic acidosis in patients with renal failure or undergoing dialysis, but further research is warranted. Aim: The aim of the study is to examine the impact of alkaline ionized water on improving outcomes among patients with hemodialysis. Methods: A parallel group randomized controlled trial was conducted involving 114 participants aged 18 years or older who had been receiving hemodialysis (HD) three times per week for at least 3 months. Structured Interviewing questionnaire, Assessment follow up tool and Kidney Disease Quality of Life Short Form tools were used to collect pertinent data. Results: Regarding the electrolytes measurements and urine output revealed high statistical significance (p = .000*) between the control and study participants except the result of PH has no statistical significance in both groups. As well as there was high statistical difference (p = .000*) regarding the study participants’ quality of life measurements at different times, especially after the intervention. Conclusions: The current study demonstrated significant improvements in primary clinical outcomes, including sodium, potassium, calcium, urea, creatinine, albumin, glomerular filtration rate, urine output, and blood pressure. Furthermore, significant improvements were observed in secondary outcomes, such as medical burden, disease symptoms, and quality of life scores. The study recommended to Develop evidence-based clinical guidelines for the safe and effective use of alkaline ionized water in hemodialysis patients, considering individual patient needs and potential contraindications.