article · Frontiers in Immunology

IgG and IgM responses to PfEMP1 domains associated with semi-immunity to clinical malaria in Burkinabe children under five

Benedicta O. Dankyi
Bernard N. Kanoi
Rattanaporn Rojrung
Takaaki Yuguchi
Issa Nébié
Sodiomon B. Sirima
Jetsumon Sattabongkot
Alfred B. Tiono
Kazutoyo Miura
Takafumi Tsuboi
Keiko Tanaka
Alphonse Ouédraogo
Hikaru Nagaoka
Yoshihiro Miyake
Eizo Takashima

2026Open accessMount Kenya University

Abstract

This study provides the first comprehensive characterization of IgG and IgM responses to a large panel of PfEMP1 domains in young children, revealing broad antibody recognition and selective opsonic phagocytosis activity. Findings from the study deepen our understanding of early-life immunity to malaria and help identify PfEMP1 regions of interest for future vaccine development.

Research topics

Malaria Research and Control
Immune responses and vaccinations
vaccines and immunoinformatics approaches

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.3389/fimmu.2026.1781670

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