article · Drug and Chemical Toxicology

<i>In vivo</i> and <i>in silico</i> toxicity profiling of a novel 1,5-benzodiazepine derivative

Hanane El Fatimi
A. Baouid
Younes Zaid
Mohamed Loughzail
Noufel Hachimi
Hachem Elaazri
Hanane Khalki
Loubna Khalki

2025Université Sultan Moulay Slimane

Abstract

toxicity prediction. In this study, ProTox predicted an oral LD50 of MAL at 3 g/kg. Based on the Globally Harmonized System (GHS) of classification, this places MAL in Category V. These findings support the potential safety of MAL for pharmaceutical formulations.

Research topics

Neuroscience and Neuropharmacology Research
Synthesis and pharmacology of benzodiazepine derivatives
Neurotransmitter Receptor Influence on Behavior

Sustainable Development Goals

6Clean Water and Sanitation

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DOI: 10.1080/01480545.2025.2606105

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