Hypertrophic cardiomyopathy in Nigeria: protocol for a systematic review

Abstract

BACKGROUND: Hypertrophic cardiomyopathy(HCM) is one of the common causes of sudden cardiac death worldwide. It is an autosomal dominant condition with a global distribution. Historically associated with a poor prognosis, advancements in cardiac imaging and management strategies have significantly improved outcomes, reducing morbidity and mortality. Although extensive research on HCM exists in more developed countries, data from Nigeria remain limited, with most studies originating from single centers. METHODS: Relevant databases such as PubMed /Medline, EMBASE, Web of Science, Google Scholar, African Index Medicus, and African Journal Online will be searched for articles published in English from January 1, 1960 to December 31, 2024. The analysis will include case reports, case control, cross-sectional, and cohort studies that reported the prevalence, risk factors, clinical profile, and outcomes of the condition. Three independent reviewers shall conduct article selection. Data extraction shall be done by 3 independent reviewers. RESULTS: The outcome measures will include the prevalence, clinical profile and characteristics of HCM in Nigeria. REGISTRATION DETAILS: This systematic review has been registered on the International Prospective Register of Systematic Reviews (PROSPERO), protocol no: CRD420251020441. CLINICAL TRIAL NUMBER: Not Applicable. CONCLUSION: This will be the first systematic review on the prevalence and clinical profile of HCM in Nigeria which will hopefully identify gaps for future research.