High Prevalence of Subclinical Hypothyroidism in Chronic Kidney Disease patients caused by Diabetes and Hypertension at Nephrology & Urology Minia University Hospital

Abstract

Background: Subclinical hypothyroidism (SCH) is becoming a major issue especially among patients with other chronic diseases like chronic kidney disease (CKD), hypertension (HTN), and diabetes mellitus (DM), but yet we have no solid data about the relationship between such diseases. Objective: our objective is to assess the prevalence of SCH among CKD patients and how it might be affected by the underlying cause of CKD at Nephrology & Urology Minia university hospital. Methods: 180 CKD patients aged between (18 and 60 years) all at stages (1 to 4) of CKD from outpatient clinics at our hospital were included. We investigated their thyroid and renal status by history, clinical examination, and laboratory tests. Results: we found a very high prevalence of SCH among CKD patients 48(26.7%) (P <0.0001). Causes of CKD significantly affected the prevalence of SCH: DM was associated with the highest prevalence of SCH (50%) (P <0.001), HTN was also associated with a rather high prevalence of SCH (40%) (P<0.001). While very low prevalence was found in obstructive uropathy, repeated urinary tract infection, congenital causes, G.N, lupus nephritis and others. Conclusion: SCH is highly prevalent among CKD patients especially when the underlying cause is DM or HTN.