article · Antibiotics
Multidrug-resistant Salmonella enterica poses a significant public health threat worldwide when spread through animal-derived foods. An investigation of retail meats and slaughterhouses in Egypt screened thirty-four non-duplicate isolates using polymerase chain reaction and DNA sequencing. Most of the isolates, specifically over eighty-two percent, were resistant to three or more classes of antimicrobial treatments. Furthermore, over forty-one percent showed an extended-spectrum beta-lactamase resistance phenotype, carrying specific resistance genes such as blaCTX-M variants and blaSHV-12 alongside narrow-spectrum types. Plasmid-mediated quinolone resistance genes were also identified in more than sixty-seven percent of the samples, including qnrA, qnrB, qnrS, and aac(6')-Ib-cr. The substantial presence of these resistant bacterial strains in the meat supply presents a serious risk of transmission to consumers through the food chain.
Foodborne bacteria that resist critical antibiotics compromise medical treatments for common infections. Identifying high rates of resistance genes in retail meat and slaughterhouses highlights vulnerabilities in meat processing and food security. Understanding which resistance genes circulate in local food supplies helps public health authorities and food safety regulators design targeted interventions to stop transmission to human populations.
The abstract does not indicate an application pathway.
AI-generated from the published abstract. Always read the original work before citing.
The emergence and spread of multidrug-resistant <i>Salmonella enterica</i> (<i>S. enterica</i>) to humans through food of animal origin are considered a major global public health concern. Currently, little is known about the prevalence of important antimicrobial resistance genes in <i>S. enterica</i> from retail food in Africa. Therefore, the screening and characterization of the extended-spectrum β-lactamase (ESBL) and plasmid-mediated quinolone resistance (PMQR) genes in <i>S. enterica</i> isolated from retail meats and slaughterhouses in Egypt were done by using PCR and DNA sequencing techniques. Twenty-eight out of thirty-four (82.4%) non-duplicate <i>S. enterica</i> isolates showed multidrug-resistance phenotypes to at least three classes of antimicrobials, and fourteen (41.2%) exhibited an ESBL-resistance phenotype and harbored at least one ESBL-encoding gene. The identified β-lactamase-encoding genes included <i>bla</i><sub>CTX-M-1</sub>, <i>bla</i><sub>CTX-M-3</sub>, <i>bla</i><sub>CTX-M-13</sub>, <i>bla</i><sub>CTX-M-14</sub>, <i>bla</i><sub>CTX-M-15</sub>, and <i>bla</i><sub>SHV-12</sub> (ESBL types); <i>bla</i><sub>CMY-2</sub> (AmpC type); and <i>bla</i><sub>TEM-1</sub> and <i>bla</i><sub>OXA-1</sub> (narrow-spectrum types). PMQR genes (included <i>qnrA</i>, <i>qnrB</i>, <i>qnrS</i>, and <i>aac(6')-Ib-cr</i>) were identified in 23 (67.6%) isolates. The presence of ESBL- and PMQR-producing <i>S. enterica</i> with a high prevalence rate in retail meats and slaughterhouses is considered a major threat to public health as these strains with resistance genes could be transmitted to humans through the food chain.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.3390/antibiotics10070881
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
