Helicobacter Pylori in Children with Type 1 Diabetes Mellitus and its Relationship with Glycemic Control and Gastrointestinal Manifestations

Abstract

Background: Children with Diabetes Mellitus (DM) can get different infections because of things like immune system problems, problems with how the stomach moves, more trips to the hospital, and stomach problems. It seems likely that (H. pylori) infection causes some of these stomach problems. Aim: The goal of this research is to improve the outcome of patients with type 1 DM. Objectives: Determine the prevalence of H. pylori in children with T1DM and look at how H. pylori infection is related to glycemic control and GI symptoms. Patients and Methods: This study was done as a critical cross-sectional study and included 180 children diagnosed with type 1 DM attending the pediatric Department at Suez Canal University Hospital. Each child was subjected to complete history taking, complete examination, glycated hemoglobin (HbA1c), and H. pylori stool antigen. Results: The frequency of H. Pylori among studied diabetic cases was 27.8%. Children with H. pylori infection had significantly higher ages than children with negative H. pylori infection (p=0.02). HbA1c was significantly increased in positive cases than in negative cases. (p =0.001). Conclusion: H. pylori is more likely to spread to children with diabetes. Also, infections caused by aggressive strains tend to happen to people who are older and have a higher HbA1c. So, people with diabetes who don't have good glucose control should get tested for H. pylori.