article · RSC Advances

Gold nanoparticles synthesized from soil-derived <i>Streptomyces</i> sp. ASM19: characterization, antimicrobial, anticancer potency targeted G2/M phase cell-cycle arrest, and <i>in silico</i> studies

Sultan Aati
Hossam M. Hassan
Gerhard Bringmann
Hanan Y. Aati
Sherine El‐Shamy
Mostafa N. Taha
Shahad H. Aati
Usama Ramadan Abdelmohsen
Ahmed A. Hamed
Hebatallah S. Bahr

202510 citationsOpen accessModern University for Information and Technology

Abstract

. Furthermore, Ac-AuNPs had total apoptotic percentages of 26.37% (SCC9) and 32.08% (SCC25), which are around 25 times higher than the control (0.95%). Additionally, it caused a notable G2/M phase cell-cycle arrest. On the other hand, molecular docking study carried out for the annotated compounds; tomaymycin (8) and nocapyrone P (5), showed considerable binding affinities compared to the co-crystallized inhibitor (fisetin) against the cyclin-dependent kinase 6 active site. Overall, the present study could be useful for nano drug delivery and may be applied for clinical studies in the future.

Research topics

Nanoparticles: synthesis and applications
Nanoparticle-Based Drug Delivery
Computational Drug Discovery Methods

Sustainable Development Goals

15Life on Land

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DOI: 10.1039/d4ra07608g

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