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article · Journal of Pathology Research Reviews & Reports

Giant Vascular Eccrine Spiradenoma of the Thigh: A Rare Painful Adnexal Tumor in a 40-Year-Old Man

2026Open accessMohammed V University

Abstract

We report a rare case of a giant vascular eccrine spiradenoma arising in the thigh of a 40-year-old man. The lesion measured 4 cm, was clinically painful, and was evaluated radiologically and histopathologically. The tumour showed the classical biphasic cellular architecture of spiradenoma with prominent vascularized stroma. Immunohistochemistry demonstrated diffuse positivity for pancytokeratin AE1/AE3, strong SMA positivity, and complete negativity for C34. Complete excision resulted in uneventful recovery with no recurrence after 12 months.

Research topics

  • Cancer and Skin Lesions
  • Sympathectomy and Hyperhidrosis Treatments
  • Nasolacrimal Duct Obstruction Treatments

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DOI: 10.47363/jpr/2026(8)189

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