article · Precision Medical Sciences
Tissue healing is a complex process involving cell proliferation, differentiation, immune modulation, and the remodelling of the extracellular matrix. Individual regenerative abilities and injury responses are influenced by genetic differences, such as single-nucleotide polymorphisms and copy-number variations, alongside epigenetic factors including DNA methylation, histone modifications, and non-coding RNA activity. Advanced high-throughput sequencing and molecular profiling techniques enable researchers to investigate how these genomic and epigenomic elements direct repair mechanisms. By integrating genetic and epigenetic data, clinicians and scientists can design personalised therapies that reflect an individual's specific capacity for regeneration and risk of scarring. In addition, the identification of biomarkers associated with healing efficiency and treatment responsiveness supports precision regenerative medicine. Targeting specific genetic variations or modifying the epigenome offers a way to enhance tissue recovery while reducing fibrosis and other adverse outcomes.
Individuals heal at different rates and face varying risks of complications such as scarring. Understanding the genetic and epigenetic factors that control tissue repair can lead to precision regenerative medicine. This approach allows treatments to be tailored to a person's specific biological profile, promoting effective tissue regeneration while preventing excessive fibrosis and related complications.
The abstract points towards the development of personalised regenerative therapies and diagnostic biomarkers that predict healing efficiency or scarring risk. Target users would be clinical practitioners and therapy developers in regenerative medicine. The work represents conceptual or early-stage research, setting out how sequencing technologies could inform molecular targets and treatment strategies rather than testing an applied product.
AI-generated from the published abstract. Always read the original work before citing.
Abstract The healing of tissues is a highly coordinated development process which includes cell proliferation and differentiation, immune modulation, and extracellular‐matrix remodeling. Genetic variation, which encompasses single‐nucleotide polymorphisms (SNPs) and copy‐number variations (CNVs), and epigenetic corrections such as DNA methylation, post‐translational changes to histones, and non‐coding RNA activity might impact regenerative capacity and individual response to injury. High‐throughput sequencing and molecular profiling technologies have made it feasible to conduct genome and epigenome‐wide studies, clarifying how genomic and epigenomic contributions impact reparative processes. For example, certain SNPs may alter signaling pathways that induce tissue growth and, likewise, epigenetic changes may alter gene‐expression patterns following injury that may affect healing. Furthermore, combining genomic and epigenomic data will allow for the development of therapies specific to an individual's capacity for repair and susceptibility for scarring. While biomarker discovery, the identification of molecular features that correlate with the efficiency of healing and/or responsiveness to treatment, would additionally provide a tangible example of precision regenerative medicine. Regenerative strategies targeting a genetic mutation or secondarily changing the epigenome to promote tissue healing would provide an opportunity to improve healing outcomes by connecting molecular mechanisms to therapeutic interventions, which would enhance regeneration while also minimizing fibrosis and other unwanted effects.
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DOI: 10.1002/prm2.70046
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