article · Frontiers in Immunology

Gene expression of tight junctions in foreskin is not affected by HIV pre-exposure prophylaxis

Emily L. Webb
Pontiano Kaleebu
Jennifer Serwanga
Andrew Sentoogo Ssemata
Stefan Petkov
Julie Fox
Thabiso Seiphetlo
Patricia Namubiru
Susan Mugaba
Limakatso Lebina
Saye Khoo
Clive M. Gray
Geoffrey Odoch
Heejin Yun
Carolina Herrera
Daniel Opoka
Neil Martinson
Azure-Dee Pillay
Laura Else
Francesca Chiodi

2024Open accessUniversity of the Witwatersrand

Abstract

TJs can limit viral entry into target cells; to affect this biological function viruses can reduce the expression of TJ proteins. Our study, on the expression and regulation of TJs in the foreskin, contribute important knowledge for PrEP safety and further design of HIV-1 prophylaxis.

Research topics

Genital Health and Disease
Oral Health Pathology and Treatment
Reproductive tract infections research

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.3389/fimmu.2024.1415475

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