article · African Journal of Pharmacy and Alternative Medicine
This study investigated the antidiabetic potential of *Strophanthus hispidus*, an African plant traditionally used for various ailments. Researchers used Gas Chromatography-Mass Spectrometry (GC-MS) to identify compounds in its n-butanol, ethyl acetate, and aqueous fractions. These fractions were then tested on alloxan-induced hyperglycaemic rats. GC-MS analysis revealed the presence of Decanoic acid methyl ester, methyl 15-acetoxy hexadecanoate, Hydrazine propyl, and Cyclobut-1-enyl methanol. All fractions significantly reduced blood glucose, creatinine, urea, bilirubin, liver enzymes, and glycosylated haemoglobin levels. They also improved body weight, lipid profile, serum insulin, hepatic glycogen, and haemoglobin levels. The identified compounds are considered potential antidiabetic agents, warranting further investigation.
This research explores a traditional African plant for new diabetes treatments. Identifying active compounds could lead to new medicines, offering hope for better management of blood sugar and related health issues. This work contributes to understanding natural sources for therapeutic agents.
This is early-stage research identifying potential antidiabetic compounds from a natural source. Further isolation and characterisation of these compounds could lead to the development of novel pharmaceutical ingredients or standardised herbal extracts for managing diabetes. Potential users would be pharmaceutical companies or natural product developers, but significant preclinical and clinical development would be required.
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Strophanthus hispidus DC (Apocynaceae) is a valued African plant that has been used as a remedy of various disease conditions. This study identified compounds present using GC-MS as well as the potential antidiabetic effects of the n-butanol, ethyl acetate, and aqueous fractions. Gas Chromatography Mass Spectrometry (GC-MS) was carried out using the Agilent 7890 A GC with a J&W HP-5MS column (30 m x 0.320 mm i.d. x 0.25 μm). The effects of the fractions (100 mg/kg each) on blood glucose levels, body weight, biochemical parameters, lipid profile, serum insulin, hepatic glycogen, and haemoglobin levels were evaluated in alloxan-induced hyperglycaemic rats. The GC-MS analysis revealed the presence of Decanoic acid methyl ester; methyl 15-acetoxy hexadecanoate; Hydrazine propyl; and Cyclobut-1-enyl methanol. A significant (p<0.05) reduction in blood glucose, creatinine, urea, bilirubin, liver enzymes, and glycosylated haemoglobin levels was observed with all fractions of S. hispidus administered compared to the untreated control. Also, an improvement in body weight, lipid profile, serum insulin, hepatic glycogen, and haemoglobin levels with S. hispidus fractions compared to the untreated control was observed. The study identifies the above-named compounds as potential antidiabetic agents in S. hispidus, with activity observed in both polar and non-polar media, warranting further investigation for compound isolation and characterization.
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DOI: 10.58460/ajpam.v5i02.196
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