Five, six and/or seven-membered rings endowed with isoxazole moiety: synthesis, antimicrobial assessment and <i>in silico</i> molecular docking studies

Abstract

AIMS: . MATERIALS AND METHODS: was rationalized by investigating the effect of substituents on inhibitory potential. RESULTS: demonsrated the strongest antibacterial and antifungal potency with minimum inhibitory concentration (MIC) value (15 µg/mL), comparable to ampicillin and clotrimazole, respectively; making it as a most promising candidate. In the same manner, it also declared the best binding energies comparable to standards. CONCLUSIONS: could be promising lead for development of potent antimicrobial drug candidates.