article · RSC Advances

Five and six membered heterocyclic rings endowed with azobenzene as dual EGFR<sup>T790M</sup> and VEGFR-2 inhibitors: design, synthesis, <i>in silico</i> ADMET profile, molecular docking, dynamic simulation and anticancer evaluations

Kurls E. Anwer
Ahmed El-morsy
Fathalla Khedr
Khaled El‐Adl
Samy Mohamady
Sanadelaslam S. A. El‐Hddad
Nour E. A. Abd El‐Sattar
Samir A. Salama
Doaa E. Keshek
Noura S. Hanafy

202338 citationsOpen accessBritish University in Egypt

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Abstract

= 0.25, 0.35, 0.40 and 0.50 μM respectively. Furthermore, the ADMET profile was evaluated for compounds 5, 6, 10 and 14 in contrast to reference drugs sorafenib and erlotinib.

Research topics

Synthesis and biological activity
Click Chemistry and Applications
Synthesis and Characterization of Heterocyclic Compounds

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DOI: 10.1039/d3ra06614b

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