article · American Journal of Physiology-Gastrointestinal and Liver Physiology

Fibroblast-specific <i>Gpx4</i> deletion exacerbates IBD via lipid peroxidation

Yuezhong Zhang
Marwa O. El-Derany
Wesley Huang
Yinzhi Ying
Zheng Hong Lee
Cristina Castillo
Tae Gyu Oh
Zoé Rosenfeld
Joel K. Greenson
Yatrik M. Shah
Yatrik M Shah

2026Open accessAin Shams University

In plain language

The abstract on record is too brief for a reliable plain-language summary, so none has been generated.

Abstract

Fibroblast-specific GPX4 deletion promotes IBD progression. Lipid peroxidation could be a potential therapeutic target of IBD.

Research topics

Ferroptosis and cancer prognosis
Immune cells in cancer
Bone and Dental Protein Studies

Read the original research

This page summarises published work. The authoritative version sits with the publisher.

View on publisher site Record on OpenAlex

DOI: 10.1152/ajpgi.00387.2025

Is something wrong with this record? Report it or request removal.

Discussion

Discuss this research

Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.

No discussion yet. Open the first thread.

New to MARATTO™? Create a free account.