Fibrinogen to Albumin Ratio and its Possible Role among Systemic Lupus Erythematosus Patients: A Review Article

Abstract

Background: There is a vast variety of clinical manifestations and illness courses that can be associated with systemic lupus erythematosus (SLE), a chronic autoimmune disorder that affects multiple systems, including the kidneys, liver, and neurological system. There is a significant gender gap when it comes to SLE, with females being diagnosed nine times more frequently than males. Patients who have SLE display essential clinical characteristics such as hypercoagulability, an exaggerated inflammatory and autoimmune responses. Within the framework of inflammation and chronic inflammation-related disorders, there is an intriguing field of study involving fibrinogen (FIB), albumin (ALB), and their ratio, fibrinogen-to-albumin ratio (FAR). We intended to outline an overview about Fibrinogen to Albumin Ratio and its possible use for assessment of disease activity of Systemic Lupus Erythematosus.Conclusion: In SLE, there is often endothelial dysfunction, which can contribute to inflammation and hypercoagulability. Elevated FAR might be associated with endothelial damage, as fibrinogen is involved in clot formation, and albumin has potential anti-inflammatory properties. FAR could serve as a marker for endothelial injury and its contribution to SLE pathogenesis.