article · The Journal of Infectious Diseases

Female Genital Tract Host Factors and Tenofovir and Lamivudine Active Metabolites

Alyssa M. Lantz
Esther Isingel
Mags Beksinska
Flavia Matovu Kiweewa
Samuel Kabwigu
Rita Nakalega
Reilly Johnson
Melanie R. Nicol

20242 citationsOpen accessUniversity of the Witwatersrand

Abstract

We investigated changes in tenofovir diphosphate and lamivudine triphosphate due to the microbiome and inflammation. While lamivudine triphosphate was not affected by either, tenofovir diphosphate appeared to be affected by local inflammation. Specifically, Th17 cells may influence tenofovir disposition.

Research topics

Reproductive tract infections research
HIV/AIDS Research and Interventions
Syphilis Diagnosis and Treatment

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1093/infdis/jiae372

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