Fabrication, Properties, and Stability of Frankincense Oil and Fatty Chitosan/Polyvinyl Alcohol-Based Wound-Healing Hydrogels

Abstract

As a hydrogel, the wound dressings made of polymers and Frankness Oil (Frank) can work incredibly well. The goal of the current study is to prepare Frank sponge hydrogels with fatty N-hexadecanyl chitosan derivatives as an antibacterial agent into polyvinyl alcohol (PVA). The bioactivity and physicochemical performance of PVA/Frank-based polymeric hydrogels were assessed. The polymeric interactions, surface morphology, water absorption capability, thermal stability, thrombogenicity and hemocompatibility were investigated by FT-IR, SEM, swelling ratio, and DSC. SEM photographs show that the PVA sponge hydrogel has a characteristic porosity structure and a noticeably lamellar appears and DSC demonstrates the thermal stability of the hydrogels. Furthermore, they demonstrated fast bleeding control because of their high-water absorption, with the PVA/Frank hydrogel having the highest water uptake efficiency (383.5%). The findings also demonstrate that Frank oil significantly impacts the degradation rate, with the PVA/Frank/DNHD-CS hydrogel exhibiting the greatest weight loss of up to 35%. The antibacterial activity was examined, and the antioxidants were tested using the DPPH assay. According to the results, PVA/Frank/CS had the strongest antibacterial activity against B. cereus (80%). Using Frank oil in sponges with PVA/Frank hydrogel resulted in a considerable increase in ABTS•+ radical scavenging activity, reaching 46% (g GAE/g film). All sponge hydrogels had hemolysis rates of less than 2%, indicating good blood compatibility and suitability for intravenous injection. These findings suggest that the hydrogels containing Frank have potential use as an antibacterial and antioxidant agent for wound care, as well as for developing novel biomaterials for dressings.