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article · Baylor University Medical Center Proceedings

Ezetimibe plus statin combination versus double-dose statin in patients with dyslipidemia and atherosclerotic cardiovascular disease risk: a comprehensive systematic review and meta-analysis of 47 randomized controlled trials

20252 citationsAlexandria University

Abstract

Ezetimibe plus statin therapy demonstrated superior lipid-lowering efficacy compared with double-dose statin therapy, with no additional clinical benefit. There was no difference in overall adverse events. There was a higher incidence of severe adverse events with combination therapy compared to double-dose statin therapy, although these events were rare and not believed to be attributable to medication.

Research topics

  • Lipoproteins and Cardiovascular Health
  • Cancer, Lipids, and Metabolism
  • Diabetes, Cardiovascular Risks, and Lipoproteins

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DOI: 10.1080/08998280.2025.2487966

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