article · Natural Product Research

Exploring the therapeutic potential of ethyl acetate fractions from algerian propolis against neuroblastoma: chemical profile <i>, in vitro</i> bioactivities and <i>in silico</i> inhibition of MDM2-P53 interaction

Safia Boulechfar
Amar Zellagui
El Hassen Mokrani
Mehmet Enes Arslan
Gürkan Berber
Dilara Esra Men
Mehmet Ozturk
Karima Oufroukh
Hatice Karataş

2026University Frères Mentouri Constantine 1

Abstract

studies validated the selective anticancer and apoptotic properties of propolis fractions, and confirmed the absence of genotoxic effects. Molecular docking and molecular dynamics revealed good binding affinities and stable interactions of Kaempferol, Naringenin, Hesperetin, Apigenin and Luteolin with MDM2. Overall, the findings highlight the potential of Algerian propolis-derived compounds as selective anticancer agents against neuroblastoma.

Research topics

Bee Products Chemical Analysis
Synthesis and bioactivity of alkaloids
Plant-Derived Bioactive Compounds

Read the original research

This page summarises published work. The authoritative version sits with the publisher.

View on publisher site Record on OpenAlex

DOI: 10.1080/14786419.2026.2662419

Is something wrong with this record? Report it or request removal.

Discussion

Discuss this research

Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.

No discussion yet. Open the first thread.

New to MARATTO™? Create a free account.