Exploring the Potential Hepatoprotective efficacy of Lepidium Sativum seeds: A Comprehensive Review

Abstract

Background: Chronic liver diseases are the leading cause of morbidity and mortality worldwide.Lepidium sativum (L. sativum) is a famous member of the Bras-sicaceae family that has been utilized for medicinal and culinary purposes for cen-turies. The hepatoprotective activity of various portions of the plant has been re-ported in several experimental and clinical trials. Aim: The current review study aimed to discuss the hepatoprotective effects of L. sativum seeds. Methods: The da-ta of this review were collected from English-language in-vivo and in-vitro studies published in electronic databases; with no time limit; including Web of Science, Scopus, MEDLINE, Google Scholar and PubMed. The searched keywords were “Lepidium sativum” and/or “chemical composition”, “Hepatoprotective”, “liver diseases”. Results: Lepidium sativum seeds significantly decreased the elevated in-flammatory markers and oxidative stress in hepatic tissues. The seed extract signifi-cantly lowered serum levels of ASP, ALT, and bilirubin. The potential molecular mechanism may be through upregulating Bcl-2 protein expression and downregu-lating caspase-3. Conclusion: Lepidium sativum seeds are promising hepatoprotec-tive natural remedy through their multi-targeted action on different pathophysio-logical mechanisms involved in liver diseases.