article · RSC Advances

Exploring the antitumor potential of novel quinoline derivatives <i>via</i> tubulin polymerization inhibition in breast cancer; design, synthesis and molecular docking

202413 citationsOpen accessMisr University for Science and Technology

Abstract

value of 17 ± 0.3 μM. The β-tubulin mRNA levels were notably reduced in MDA-MB-231 cells treated with compound 4c which is similar to the effect observed with colchicine treatment. Docking studies revealed that compound 4c interacted well with crucial amino acids in the active site.

Research topics

Synthesis and biological activity
Synthesis and Biological Evaluation
Synthesis of heterocyclic compounds

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1039/d4ra04371e

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