Experimental Design for the Formulation and Optimization of Phloroglucinol Mouth Dissolving Tablets

Abstract

The purpose of the present study was to prepare and evaluate Phlorogluinol mouth dissolving tablets using experimental mixture design. Ten different formulations were generated based on three types of disintegrants (croscarmellose sodium, crospovidone and microcrystalline cellulose) by using simplex lattice design with Minitab 1.6® software. Tablets were prepared by direct compression technique. The percentage of drug release at 5min, 30 min and the disintegration time were statistically analyzed to get the optimized formulation. Drug content, hardness, friability and mass uniformity were carried out on the optimum formulation as further experiments. Tablets containing the mixture of the three disintegrants provided the best release profile and the fast disintegration. The results of the quality control tests for the optimized formulation complied with the requirements of the European Pharmacopoeia 9.2.