Experimental Assessment of Anti-arthritic and Anti-diabetic Effects of Antidesma madagascariense Lam

Abstract

Systematic evaluation of plants used in the traditional medicines was considered as an approach that was able to provide more promising information regarding their therapeutic value and was beneficial in addressing the increasing demand for newer agents to fight infections and diseases. With this view, the plant Antidesma madagascariense Lam. was selected for our research. As the continuation of our previous effort, the present study was focused on the in vivo evaluation of anti-arthritic and anti-diabetic activity of methanol extract of A. madagascariense. Initially, acute toxicity of the extracts was evaluated and the effective dose (ED50) was fixed. Anti-arthritic activity of the extract was evaluated by Complete Freund’s adjuvant (CFA) induced arthritic animal models. Anti-diabetic activity of the extract was evaluated by streptozotocin-induced diabetes mellitus animal models. Two doses of test extract, low dose and high dose (250 and 500mg.kg-1), were subjected to the evaluation. In these evaluations, methanol extract in the dose of 500mg.kg-1 was found to show a significant result. Further studies of this extract in future were suggested as they might yield significant results that would be useful for the development of new chemotherapeutic agents.