article · PLoS ONE
Reducing feed expenses is a central challenge in commercial poultry production. An evaluation examined whether supplementing low-energy diets with commercial multienzyme preparations could enhance digestion, nutrient uptake, and growth in broiler chickens. Over three thousand day-old chicks were assigned to diets including standard feed, a low-energy control diet, or low-energy feed supplemented with one of four commercial enzyme formulations. Chicks receiving diets supplemented with Avizyme or Hemicell achieved significantly improved growth performance compared with birds on unsupplemented low-energy feed. Furthermore, Avizyme substantially upregulated the expression of key intestinal transporter and immune-related genes, including PEPT1, GLUT2, ACC, and IL-2, compared with the standard control diet. Overall, multienzyme supplementation, with Avizyme demonstrating the highest effectiveness followed by Hemicell and Megazyme, supports bird growth and enhances nutrient absorption pathways while lowering feed costs.
Feed makes up a substantial portion of poultry farming costs. Using low-energy diets supplemented with specific commercial enzyme formulations enables farmers to maintain or improve bird growth and nutrient absorption while spending less on expensive feed components. Understanding how these additives stimulate intestinal nutrient transporters provides biological validation for strategies aimed at improving poultry production efficiency.
The findings apply directly to poultry producers and animal feed manufacturers seeking to reduce ration formulation costs without compromising bird performance. Because the evaluated multienzymes are existing commercial products tested at manufacturer-recommended doses in a large flock trial, the approach is applied and ready for practical implementation in broiler operations using low-energy feeds.
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Diminishing the cost of broiler chicken diet is a critical issue in the poultry industry. Numerous studies were performed to achieve this pivotal objective by diet supplementation with alternative feed additives. In the current study, low-energy broiler rations were supplemented with different commercial multienzyme formulations to minimize the cost, and increase the digestibility and absorption of the digested macronutrients. Cobb Avian 48 broiler chicks (mixed sex, 1-d-old, n = 3120) were randomly allocated into six groups, and each group was subdivided into four replicates (130 birds per replicate). The birds were randomly allocated into a control group fed basal diet (CB); control group fed low-energy diet (CL); and birds fed low-energy diets supplemented with different enzyme formulations. The enzyme formulations used were Xylam 500® (CLX group), Hemicell® (CLH group), Avizyme® (CLA group), and Megazyme® (CLM group,) following the doses recommended by the manufacturers. The growth performance of CLA and CLH group birds was significantly improved when compared with CL. In comparison with CB, Avizyme® significantly (p < 0.001) increased the intestinal PEPT1, GLUT2, ACC, and IL-2 expression; PEPT1 facilitates the absorption of micronutrients. In conclusion, exogenous multienzyme complexes may be included in the low-energy diet to enhance the performance of broiler chickens (Avizyme® ˃ Hemicell® ˃ Megazyme®), and reduce the diet cost by up-regulating the expression of intestinal nutrient transporter genes, and improving the immunity and serum biochemical parameters of broiler chickens.
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DOI: 10.1371/journal.pone.0198085
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