Evaluation of Therapeutic Effect of Spirulina in Patients with Geographic Tongue: A Randomized Double Blind Controlled Clinical Trial

Abstract

Objective: The aim of this study is to evaluate the therapeutic effect of spirulina in patients with Geographic Tongue Materials and Methods: Twenty patients diagnosed with symptomatic benign migratory glossitis will be selected. Research ethical committee will review the protocol and the procedure will be explained to the patients and they will sign an informed consent.Seven days after the diagnosis and selection of patients with (BMG), the atrophic areas will be determined and the patients will attend a control checkup in order to exclude those with constant changing patterns of the red atrophic areas with raised keratotic margins. The selected patient according the inclusion and exclusion criteria will be randomly allocated using computer generated allocation concealment into two groups; Group I (study group): Will include 10 patients with symptomatic BMG receiving Spirulina tablet Supplementation triple daily. Group II: Will include 10 patients with symptomatic BMG receiving placebo treatment for one month. (control group). Intensity of the discomfort will be monitored by the patients using the Visual Analogue Scale (VAS). Saliva will be collected from all included patients to evaluate interlukin -8 (IL -8).