Evaluation of the anti-hyperglycemic and anti-dyslipidemic potential of the hydroethanolic extract of Graptophyllum pictum (Acanthaceae) aerial parts in streptozotocin-nicotinamide-induced diabetic Wistar rats

Abstract

Context: was chosen for the study due to its traditional claim of reducing blood glucose levels and established glucosidase inhibitory action. Objective: (L.) Griff aerial part was evaluated for hypoglycemic, antihyperglycemic, antidyslipidemic, and protective effects on liver enzymes in streptozotocin (STZ)-nicotinamide (NA)-induced diabetic Wistar rats. Methods: Diabetes was induced in Wistar rats using an intraperitoneal injection of STZ (60 mg/kg) just 15 min after injecting NA (120 mg/kg). Glibenclamide (10 mg/kg) as a standard and hydroethanolic extract (250 and 500 mg/kg) were used for the treatment of diabetic rats. Throughout the study (21 days), normal and diabetic control animals were given only normal saline (5 mL/kg, p.o). Results: < 0.01, alanine aminotransferase). Conclusion: hydroethanolic extract validates its use as an anti-diabetic agent and may offer a new perspective on type 2 diabetic therapy.