Evaluation of Endoscopic Repair of Cerebrospinal Fluid (CSF) Rhinorrhea with Single Layer Graft versus Multilayers Graft

Abstract

Background: Endoscopic repair of skull base defect is the treatment of choice in cases of CSF rhinorrhea.Objectives: To evaluate the results of endoscopic repair with single-layer grafting versus multi-layer grafting in cases of CSF rhinorrhea.Patients and methods : This study included 50 patients with CSF rhinorrhea. They are divided into two groups. Group A included 25 patients who underwent repair of the defect using a single-layer graft. Group B included 25 patients who underwent repair by multi-layer graft. Postoperative follow-up of all cases for one year.Results: This study included 50 patients: 34 were females (68%) and 16 were males (32%) with the mean age of 39.9 ± 12.03 . Group A included 25 patients. The mean age 39.9 ± 12.95 in comparison to 39.8 ± 11.69 years in Group B showed no significant difference. Group A included 72% females and 28% males compared to 64% females and 36% males in Group B with no significant difference. As regards etiology, the most common cause in Group A is neoplastic, but the most common cause in Group B is spontaneous causes. The comparison between group (A) and group (B) regarding defect data showed no significant differences. Comparison between the two studied groups regarding grafts and flaps showed a highly significant difference was observed between the group (A) and group (B) in the use of autologous fat grafts, fascia Lata grafts, Naso-septal flap, bone grafts, and free mucosal grafts. Comparison between group (A) and group (B) regarding postoperative outcomes revealed no significant differences in all parameters.Conclusion: Both techniques showed similar outcomes, with no significant differences in complications or CSF leak recurrence.