article · Journal of Radioanalytical and Nuclear Chemistry
Abstract There is limited information on utilizing commercially supplied [ 18 F]Fluoride from an off-site cyclotron for the synthesis of radiopharmaceuticals. This study explored the production of the PET hypoxia marker [ 18 F]FMISO, using the Scintomics® GRP module and distantly produced [ 18 F]Fluoride, which lacks published data. A radiochemical yield of 27.4 ± 3.6% ( n = 5) and high radiochemical purity were achieved in synthesis time of 48 min. The [ 18 F]FMISO met all Ph. Eur. standards, demonstrating the consistency and reliability of the module in generating a clinical-grade radiopharmaceutical using off-site produced [ 18 F]Fluoride, but available patient doses were severely limited.
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DOI: 10.1007/s10967-024-09734-w
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