article · PLoS Medicine

Evaluating the biomedical and behavioral drivers of HIV incidence decline in adolescent girls and young women in Uganda: A mathematical modeling study

Adam Akullian
William J. M. Probert
Philip Kreniske
Oliver Ratmann
Joseph Kagaayi
John Santelli
Larry W. Chang
M. Kate Grabowski
Daniel Bridenbecker
Robert Ssekubugu
Thomas C. Quinn
Ronald H. Gray
Ronald M. Galiwango
Maria J. Wawer
Godfrey Kigozi
Christophe Fraser
Daniel Breidenbecker
Jeffrey W. Imai-Eaton
Victor Ssempijja
Gertrude Nakigozi
Fred Nalugoda
Steven J. Reynolds
David Serwadda

2026Open accessMakerere University

Abstract

Both biomedical HIV interventions and broader behavioral changes contributed to declines in HIV incidence among AGYW. Sustaining continued incidence declines in young women will require maintaining both the protective changes in sexual behaviors and effective biomedical interventions.

Research topics

HIV/AIDS Research and Interventions
Adolescent Sexual and Reproductive Health
Genital Health and Disease

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1371/journal.pmed.1004993

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