Euphorbia resinifera propolis administration improves memory ability in high fructose treated rats

Abstract

Propolis, a substance crafted from plant resin by honeybees, serves to maintain a hygienic environment within their hives and has been linked to improved cognitive function due to its antioxidant properties. This study aims to assess the influence of high fructose (HF) during prepuberty and adolescence and the Euphorbia resinifera propolis supplementation on memory in adult rats. 24 Wistar rats were distributed into three groups of 8 rats. G1 control group, don’t receive any treatment; G2: F, group subjected to high fructose (23%) for 6 weeks and G3; F-MEP received fructose duringsix weeks and after received a 15-day treatment of 200mg/kg/day of Euphorbia resinifera propolis methanolic extract of (F-MEP). High fructose administration during prepuberty and adolescence resulted in long-term memory loss and impaired working memory in adult rats. Euphorbia resinifera propolis supplementation significantly increased the recognition index (p < 0.01) compared to the group F, and was able to protect against this effect on F-induced memory (p < 0.01) by a decrease in the synthesis of attacking factors and/or an increase in the production of protective factors. These findings suggest that propolis extract, with its antioxidant compounds, improves memory performance and justifies its use in traditional medicine by the Moroccan population. Euphorbia resinifera propolis supplement could serve as a therapeutic agent for memory disorders caused by fructose feeding.