article · Natural Product Research
This study provides novel findings on the ameliorative effect of hyperoside isolated from <i>Marsdenia latifolia</i> leaves (HIGLL) in reproductive health challenged by manganese toxicity. The study investigated the efficacy of HIGLL on male fertility in rats exposed to manganese chloride (MnCl<sub>2</sub>). The rats received either MnCl<sub>2</sub> (30 mg/L) or in combination with HIGLL (100 mg/kg or 200 mg/kg). MnCl<sub>2</sub> reduced fluid intake, organ-body weight, body weight; sperm count, sperm viability, sperm density, sperm motility, semen viscosity, daily sperm production, testicular sperm number; testosterone, follicle-stimulating and luteinising hormones, oestradiol, testosterone/oestradiol ratio; G6PDH, ALP, glucose, NO, acid phosphatase, sialic acid, 17-β-HSD, superoxide dismutase, CAT, GST, GSH, and T-SH without modifying the semen pH and volume, while it correspondingly raised the abnormalities associated with morphology of sperm cells in head, neck, and tail; H<sub>2</sub>O<sub>2</sub> and lipid peroxidation levels. HIGLL abrogated the damaged histoarchitecture of the testes and epididymis caused by MnCl<sub>2</sub>. HIGLL can serve as a therapeutic agent in the management of male reproductive disorders related to oxidative stress and endocrine disruption.
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DOI: 10.1080/14786419.2024.2423041
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