Estimating level of serum PLGF and sFLT-1 in Egyptian pregnant women with and without preeclampsia

Abstract

Pre-eclampsia is considered one of the leading causes of maternal and foetal mortality and morbidity worldwide, pre-eclampsia is a prevalent pregnancy condition. As a result, we must immediately begin working on practical and inexpensive diagnostic tools that will allow for the early detection of high-risk women, which will pave the way for more precise preventative measures and treatment. The main object is to reduce the number of maternal fatalities caused by preeclampsia. The increased circulating antiangiogenic substances that originated from a hypoxic placenta is associated with pre-eclampsia (PE). Objective : the aim of this study To estimate the values of serum sFlt-1 and PLGF in the diagnosis and prediction of pre-eclampsia in the Egyptian pregnant women Patients and methods: 160 pregnant women with pre-eclampsia and 64 pregnant women with normal pregnancy were included in our study. Patients with Pre-eclampsia were subdivided into mild and severe as well as early-onset and late-onset. serum PLGF and sFlts were measured. Results: serum PlGF was statistically significant lower in pregnant patients with preeclampsia (74.5 ± 22 vs. 236.1 ± 108.6, p <0.001), while serum sFlt-1 and sFlt-1/PlGF ratio were statistically significant higher in pregnant patients with preeclampsia (4264.2± 804.5 vs. 373.4 ± 62.7, p <0.001; 73.1 ± 66.5 vs. 1.8 ± 0.6, p <0.001 respectively) as compared to control group Conclusion We concluded that PlGF and sFlts-1 are useful in diagnostic and prediction of pre-eclampsia