preprint
Abstract Type 2 diabetes (T2D) is a complex metabolic disorder influenced by genetic, epigenetic, and environmental factors. Triglycerides and lipoproteins play a role in the development and progression of both macro and micro vascular complications of diabetes and our previous studies demonstrated a correlation between DNA methylation of genes associated with diabetes and diabetes metabolic pathways. We now investigate the association of DNA methylation in diabetes with alterations in lipoproteins and triglycerides and genomic risk scores (GRS), in subjects from the Qatar Biobank population. We have identified TXNIP and PFKFB2 gene methylation to have a mechanistic link with altered lipoproteins and triglycerides in T2D.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1101/2025.04.21.25326110
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
