Electrochemical Study of Uranyl-Paracetamol Interactions in Solution: Cyclic Voltammetry and Molecular Docking Approaches

Abstract

The electrochemical behaviour of paracetamol was investigated in various electrolyte environments, with a focus on its interaction with uranyl ions in alkaline medium. Cyclic voltammetry revealed evidence of complex formation, supported by shifts in peak potentials and increased current responses. Thermodynamic parameters were estimated from electrochemical data, confirming the stability and spontaneity of the complexes. Molecular docking studies with viral (7JWY) and cancer-related (5IXB) proteins were also performed to evaluate theoretical binding affinity. The findings suggest that paracetamol can form stable coordination complexes with uranyl ions and potentially interact with biologically relevant targets.