Electrocatalytic effects of a clicked film of an asymmetric A3B (A = 3-oxyflavone, B = α-(ethynyl)benzyl alcohol) CoPc complex on a glassy carbon electrode for the detection of dopamine

Abstract

Herein, a glassy carbon electrode (GCE) was modified by an asymmetric metallophthalocyanine (MPc) complex, A3B-CoPc-flav (where A = flavonyloxy substituent and B = an alkynyloxy substituent/molecular mast). The modification of an electrode was achieved via electrochemical grafting followed by clicked chemistry between the diazonium-functionalized GCE and the a-CoPc-flav3 to afford the CME, GCE|clicked-a-CoPc-flav3. The CME was utilized as a electrocatalytic detector for a neurotransmitter and emerging environmental pollutant, Dopamine (DA) under optimized conditions. The response for GCE|clicked-a-CoPc-flav3 was linear in the concentration range of 2 μM to 14 μM, attaining respective limits of detection and quantification of 0.311 and 0.942 µM with high reproducibility (%RSD of 2.25 %, N = 3). Interference studies were conducted, revealing a marginal shift in the DA peak potential in the presence of interfering analytes. Despite this shift, the peak current intensity of DA remained largely unaffected, affirming the selectivity and accuracy of the CME. The analytical capabilities of the CME were further assessed using real water samples. The percentage recovery obtained (97.1 %) was comparable to the results achieved through the well-established HPLC-MS method (113 %).