Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Stage II or Stage III Periodontitis: A Randomized Controlled Trial with Microbiological Analysis

Abstract

Background: Non-surgical periodontal therapy, with or without adjunctive therapies, is an effective method in treatment of periodontitis. It decreases Pocket depth and results in formation of some new attachment. The comparison of local effects of non-surgical periodontal therapy only to scaling and root surface planning with the aid of 0.2% hyaluronic acid as local therapeutic agent regarding clinical parameters and microbiological analysis of main pathogenic periodontal pathogens (Aggregatibacter Actinomycetumomitans and Porphyromonus gingivalis) Using real time PCR was the aim of the study.Subjects and methods: the current study was performed on twenty-eight patients diagnosed with localized periodontitis stage (II) or (III) grade (A). Patients were randomly divided into 2 groups with 14 participants in each. Group (I) "intervention group'' candidates treated with scaling and root surface debridement with local application of 0.2% HA application in situ gel while group (II) had scaling and root surface debridement only. Microbiological indices were gathered at time interval: baseline, after 1 week and after 1 month. Results: statistical results of our study showed advancement in MSBI, PD and CAL parameters in both groups after 1 and 3 months follow up. There was no statistically significant difference regarding microbiological analysis between 2 groups after 3 months.Conclusion: we conducted from the current study that the application of 0.2% HA once in patients with stage II or III periodontitis had limited effect regarding clinical and microbiological analysis.