article · The Journal of Infectious Diseases

Efficacy and Safety of Artemether-Lumefantrine Against Uncomplicated Falciparum Malaria Infection in Tanzania, 2022: A Single-Arm Clinical Trial

Jessica Laury
Muhidin K. Mahende
Marian Warsame
Jovin Kitau
Florida Muro
Erasmus Kamugisha
Kefas Mugittu
Dunstan R. Bishanga
Billy Ngasala
Marko Bajic
Deus S. Ishengoma
Bilali Kabula
Frank Chacky
Naomi Serbantez
Sixbert I. Mkumbaye
Mercy G. Chiduo
Filbert Francis
Chonge Kitojo
Celine I. Mandara
Maimuna Ahmed
Erik J. Reaves
Debora C. Kajeguka
Reginald A. Kavishe

20247 citationsOpen accessCatholic University of Health and Allied Sciences

Abstract

Artemether-lumefantrine remains highly efficacious in 3 regions of Tanzania, but the PCR-corrected efficacy in Pwani fell below the WHO-defined 90% threshold at which policy change is recommended. Implementing strategies to diversify artemisinin-based combination therapies to ensure effective case management in Tanzania is critical.

Research topics

Malaria Research and Control
Mosquito-borne diseases and control
Computational Drug Discovery Methods

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1093/infdis/jiae425

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