Effet du paracétamol sur la tension artérielle: Protocole d'une revue systématique

Abstract

INTRODUCTION: Paracetamol is widely used as a first-line treatment for chronic pain because it is thought to be safe. Unlike non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol is thought to have no cardiovascular effects and specially no effect on blood pressure (BP). However, some studies suggest that paracetamol may increase BP. Thus, our aim was to address a systematic review in order to investigate the effects of regular paracetamol intake on BP. METHODS: To address this systematic review, a search on PubMed, Cochrane and Scopus is planned. A search on grey literature, registries, thesis and congress abstracts will be performed. We will include randomized clinical trials, interventional studies and observational studies. Studies on child bearing women and those with eclampsia or preeclampsia will be excluded. Besides, only studies using recommended dosage of paracetamol will be included. The primary outcomes of interest will be the change of BP before and after the intake of paracetamol. DISCUSSION: Change of BP will be assessed on patients taking paracetamol. Any previous cardiovascular disease or hypertension will be raised in order to identify if there are risk factors of hypertension under paracetamol.