Effects of Physical Activity on Pakinson's Disease Patients

Abstract

Parkinson's disease (PD) is the most common movement disorder worldwide, of which neuroprotective or neurorestorative therapy is not yet available. The current line treatments are believed to be effective in alleviating PD symptoms, but as the disease progress, various complications appear, and the treatment becomes challenging. Hence, the role of nonpharmacologic therapies in the treatment of PD is of great interest and can be useful to delay and slow the disease progression. Increasing evidence shows the important role of physical activity (PA) in the management and even the prevention of the disease. Several mechanisms are thought to explain the beneficial effect of exercise in PD. However, the exact neurobiological mechanisms underpinning this benefit are not fully understood. This chapter will discuss the benefit of exercise in PD patients and the possible molecular mechanisms by which PA could lead to these beneficial effects.