Effect of Sacubitril/Valsartan on heart rate turbulence in patients with heart failure with reduced ejection fraction

Abstract

Background: HRT is noninvasive tool that predicts sudden cardiac death and arrhythmic events in patients with heart failure with reduced ejection fraction Aim: the current study aimed to know the effect of sacubitril / valsartan drug (Entresto) on the (HRT) in the patients with heart failure with reduced ejection fraction (EF ≤ 35 %). Methods: We included 42 patients with heart failure with reduced ejection fraction (EF ≤35 %). Patients with normal sinus rhythm and at least 5 PVCs fulfilling the criteria for measurement of HRT in Holter. A comparative study was done between HRT parameters before and 3 months after sacubitril / valsartan treatment. Results: We found that HRV index, mean HR, Maximum HR and total number of beats in 24 hrs. were improved after 3 months of sacubitril/ valsartan treatment HRT score did not improve but it predicted development of complications . Conclusion: Although HRT score did not improve after 3 months of sacubitril/ valsartan, HRT could predict development of complications such as sudden death , VT , Runs of salvos and PVCs more than 10% .